BRAF and melanoma: The other gene, BRAF, encoding a protein attributing to the RAF family of serine/threonine protein kinases, takes part in tumor cell growth, invasion, and early diagnosis in melanoma [27, 28], and BRAF mutation was connected with metastatic disease in consensus molecular subtype-1 (CMS1) MSS cancers, resulting in poor prognosis in primary colorectal cancer [29].