SHBG and Insulin resistance: Studies investigated the effects of metformin on ten outcomes (FSH (follicle-stimulating hormone), HOMA-IR (homeostasis model assessment of insulin resistance), LH (luteinizing hormone), SHBG (sex hormone-binding globulin), HDL (high-density lipoprotein) cholesterol, LDL (low-density lipoprotein) cholesterol, TC (total plasma cholesterol), TG (triglycerides), FBG (fasting blood glucose), and androstenedione).