The α, β-meATP further promoted an increase in the expression level (P < 0.05, vs. MG, Figure 2(b)), while A-317491 and EA inhibited P2X3 mRNA expression (P < 0.01, vs. MG, Figure 2(b)), consistent with the previous results, suggesting that EA may relieve the visceral hypersensitivity by directly regulating the P2X3 mRNA expression in the colon. This evidence concerns the gene P2RX3 and myasthenia gravis.