Our previous clinical and animal studies have also confirmed the effectiveness of acupuncture in the treatment of IBS [11–13] and initially revealed that the P2X2, P2X3, and P2Y1 receptors in the peripheral neurons of the colon and in central neurons participate in the acupuncture-mediated relief of the visceral pain in IBS. The gene discussed is P2RX2; the disease is irritable bowel syndrome.