A few of articles reflected that some indexes could affect the proliferation and invasion of GC by regulating HGF or MMP9 (Appleby et al., 2017; Matsumoto et al., 2017; Zhang et al., 2017; Ding et al., 2018; Wang R. et al., 2018), but the function of these six genes in GC was still not well-known, especially FBN1, FN1, and VCAN (Lee et al., 2016; Sakai et al., 2016; Wang J. et al., 2018; Jiang et al., 2019). The gene discussed is VCAN; the disease is gastric cancer.