EBV deficient in the immediate early lytic EBV transactivator BZLF1 was compromised in its ability to cause DLBCL-like lymphomas in humanized mice, KSHV co-infection increased lytic EBV replication and lymphomagenesis, and BMLF1 specific CD8+ T cells were able to transiently control lytic EBV infection after their adoptive transfer (18, 23, 30). The gene discussed is CD8A; the disease is lymphoma.