Noteworthy, a previous report showed that intrahepatic CD4+ T cells were reduced during methionine choline-deficient (MCD) diet-induced NAFLD in inducible liver-specific MYC oncogene (both ON and OFF) transgenic mice, although these T cells (in MYC-ON mice) were shown to be activated (CD69+) and to express IL-17A and IFNγ (35). This evidence concerns the gene CD4 and metabolic dysfunction-associated steatotic liver disease.