CD4 and metabolic dysfunction-associated steatohepatitis: While the activation of CD4+ T cells in Ma et al.’s model supports our findings and those of other groups who have identified the contribution of Th17 and Th1 CD4+ T cells in NASH inflammation, lower levels of intrahepatic CD4+ T cells in Ma et al.’s model compared to other NAFLD mouse models (including our HIL mouse model) may be explained by the presence of MYC oncogene in the former (11, 13, 30, 35).