Consistent with our data, Omar et al. reported that wildtype C57BL/6 mice placed on an 8-week Surwit high fat-high sucrose diet (D12331; Research Diet Inc) exhibited modest insulin resistance compared to severe insulin resistance in those on high fat diet (D12492; Research Diet Inc), and this difference was due to increased secretion of total insulin (22). The gene discussed is INS; the disease is Insulin resistance.