TGFB1 and Other metabolic disease: Type 2 diabetes mellitus is characterized by a metabolic disorder between increased circulating levels of pro-inflammatory cytokines like interleukin- IL-1, IL-6, tumor necrosis factor-(TNF-)α, transforming growth factor-β (TGF-β) and decreased anti-inflammatory cytokines like IL-4, IL-10, IL-13 (34), which are involved with peripheral insulin resistance (8) and beta cell apoptosis in T2DM (34).