Adult-onset Still’s disease (AOSD) is a systemic, multigenic autoinflammatory disease characterized by cardinal manifestations of fever, arthritis and/or arthralgia, skin rash, sore throat, leukocytosis, and excessive neutrophil proportion, in combination with other symptoms, such as myalgia, pericarditis, pleuritis, and elevated erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and ferritin levels (1–3). The gene discussed is CRP; the disease is Increased total leukocyte count.