Furthermore, we explored the urinary levels of LRG1, ORM1, and ORM2 in patients with AOSD, rheumatoid arthritis (RA), neoplasms, and infections and healthy control (HC) subjects by enzyme-linked immunosorbent assay (ELISA) and determined the correlation between the urinary levels of LRG1, ORM1, and ORM2 and clinical symptoms of AOSD. This evidence concerns the gene LRG1 and rheumatoid arthritis.