The production of type 2 cytokines (IL-4, IL-5, IL-10, and IL-13), as well as granulocyte-macrophage colony-stimulating factor (GM-CSF), by these cells induces eosinophilia, M2 macrophage polarization, and the secretion of immunoglobulin G1 (IgG1), IgG4, and IgE (7–11). This evidence concerns the gene IGHE and Increased total eosinophil count.