MIF homologs from B. malayi (99) and T. spiralis (100) functionally reflect host MIF proteins, e.g., regarding chemotactic effects on monocytes, whereas the MIF homolog from A. simplex (As-MIF) showed direct anti-inflammatory activity on OVA-induced AAI, where it suppressed the production of TH2 cytokines (IL-4, IL-5, and IL-13), as well as eosinophilia and goblet cell hyperplasia in the airways. This evidence concerns the gene IL4 and Increased total eosinophil count.