It has been demonstrated that once-weekly topical application of the carcinogen 7,12-dimethylbenz [a] anthracene (DMBA) to the skin of WT mice led to the development of squamous-cell carcinomas (SCCs) after 8–15 weeks associated with high concentrations of serum IgE and infiltration of IgE-bearing basophils in skin and tumors (224). Here, IGHE is linked to squamous cell carcinoma.