HLA-DRB1 and adult-onset Still disease: In terms of genetic susceptibility, several human leukocyte antigens (HLAs) have been reported to be associated with AOSD including HLA-Bw35, -DRw6, HLA-DR4, HLA-B17, HLA-B18, HLA-B35, and HLA-DRB1 (6, 13).