Recently our group identified epigenetic silencing of STING in KRAS-LKB1 (KL) mutant cancer cells, due to an autophagic defect and consequent cytosolic accumulation of mitochondrial DNA, resulting in the inhibition of STING-TBK1-IRF3 mediated type I interferon signaling and impaired production of T cell chemoattractants such as CXCL10 (5). This evidence concerns the gene IRF3 and cancer.