CXCL10 and neoplasm: This calculation revealed supra-additive upregulation of many of the same cytokines/chemokines in LKB1-reconstituted tumor spheroids co-cultured with MVNs, including CCL2 and CXCL10, while there were some differences such as IL-6, which was amplified, and CCL5, which was suppressed (Figures 2C,D).