Importantly, we also observed that cancer cell cGAS deletion significantly decreased expression of both CXCL10 and IFN-β in co-cultured HUVECs, providing direct evidence that ablation of 2′3′-cGAMP export from tumor cells suppresses STING signaling in endothelial cells (Figures 5H,I). The gene discussed is CGAS; the disease is neoplasm.