IFNA1 and AIDS: This could be an important contributing factor, not only to HPV persistence and cervical cancer development, but also to increased susceptibility to HIV considering that reduced activity of type I IFN receptor delay/decrease immune responses and accelerate AIDS progression and that high levels of type I IFN at first induces antiviral response protecting mucosa, but increase HIV susceptibility repressing several IFN effects in sustained high level condition (57).