This could be an important contributing factor, not only to HPV persistence and cervical cancer development, but also to increased susceptibility to HIV considering that reduced activity of type I IFN receptor delay/decrease immune responses and accelerate AIDS progression and that high levels of type I IFN at first induces antiviral response protecting mucosa, but increase HIV susceptibility repressing several IFN effects in sustained high level condition (57). This evidence concerns the gene IFNA1 and cervical carcinoma.