It demonstrated SARS-CoV-2 specific CD4+ T cells in 100% of COVID-19 convalescent patients, with the majority of responses against S protein, correlating with the magnitude of anti-SARS-CoV-2 IgG and IgA titers, but as well responses against M and N proteins in all patients, accounting for 11–27% of the total CD4 + responses. This evidence concerns the gene PROS1 and COVID-19.