IFNG and Crohn disease: The clinical accuracy of IGRAs seems to be negatively affected in patients with immune-mediated inflammatory diseases (IMIDs) (37) such as Crohn's disease, where the function of immune cells is suppressed (38), as well as in patients on immunomodulatory drugs such as teriflunomide, which exerts an inhibitory effect on T-cell activation, and outcome in QuantiFERON results changing from positive to negative with marked reduction in IFN-γ (39).