In addition, genetic variants in the genes encoding e.g., surfactant protein C (SFPTC) (57, 58) and in the promotor region of mucin 5B (MUC5B), increase the risk of IPF development (59–61), while MUC5B has shown not to contribute to SSc-ILD (62). The gene discussed is MUC5B; the disease is interstitial lung disease.