CCL2 and systemic sclerosis: In addition to enhanced levels of pro-fibrotic mediators, levels of pro-inflammatory cytokines and chemokines (including IL-8, IL-1α, IL-10, macrophage inflammatory protein-1α and MCP-1) and neutrophil-derived alpha-defensins (human neutrophil peptides (HNP), are increased in BALF from SSc-ILD patients (29, 47).