Our previous work indicated that Bcl2L12 was involved in aberrant TH2 polarization by promoting TH2 cell differentiation and interfering with TH2 cell apoptosis (10, 23), which might be associated with the dysregulation of immune tolerance in patients with allergic rhinitis (21), and TH2-biased inflammation in the intestine (10, 24). Here, BCL2L12 is linked to allergic rhinitis.