Treatment with the Gal-3 inhibitor GR-MD-02 in combination with the stimulatory anti-OX40 monoclonal antibody promoted antigen specific T cell expansion and survival of mice bearing TRAMP-C1 tumors, reduced lung metastases in the 4T1 model, and showed anti-tumor activity in other mouse models (81). The gene discussed is LGALS3; the disease is neoplasm.