However, in one report of 145 prostate cancer patients subjected to radical prostatectomy, the intensity of Gal-3 expression in carcinoma cells significantly associated with prostate specific antigen (PSA) relapse in univariate analysis, and exclusive cytoplasmic localization of Gal-3 was an independent prognostic indicator of biochemical progression after radical prostatectomy (14). This evidence concerns the gene KLK3 and Familial prostate cancer.