While in the healthy human and mouse prostate, Gal-3 showed a weak immunostaining primarily localized in the cytoplasm (Figure 6B), in human PIN lesions Gal-3 staining was rather heterogeneous and intense, and mainly cytoplasmic (Figure 6B), thus confirming previous findings (14). The gene discussed is LGALS3; the disease is prostate intraepithelial neoplasia.