TNC and neoplasm: As an example, by interacting with N-linked oligosaccharides on the surface of mammary carcinoma cells, Gal-3 induces activation of α5β1 integrin, the target of Tenascin-C on T cells (30), favoring, in this case, fibronectin fibrillogenesis, and fibronectin-dependent spreading and motility of tumor cells (68).