CEACAM5 and esophageal squamous cell carcinoma: Different TAAs have been investigated for their potential therapeutic relevance (178): cancer/testis antigens such as melanoma-associated antigen (MAGE)-A3 (179, 180), MAGE-A4 (35, 181), and New York esophageal squamous cell carcinoma (NY-ESO)-1 (182); oncogenes/oncosuppressors such as WT1 (50) and p53 (183); tissue-restricted/differentiation antigens such as MART-1 (28, 34), gp100 (29), or CEA (31).