Previous studies have shown that accumulation of IPP and DMAPP in cancer cells induces abnormal expression of MHC Class I polypeptide-related sequence A and/or B (MICA/MICB) and UL16-binding proteins (ULBPs), thus activating γδ T cells by binding MICA/MICB and ULBPs to NKG2D (a lectin-type activating receptor, which is expressed on the surface of the most NK and NKT cells) (52–54). This evidence concerns the gene MICA and cancer.