A recent study showed that Phloretin could enhance the cytolytic effects of γδ T cells on colon cancer cells by facilitating the proliferation of IFN-γ producing γδ T cells, and the underlying mechanism might be associated with the increased expression of PFP, GraB, and CD107a as well as the activation of the Wnt signaling pathway (75). Here, IFNG is linked to malignant colon neoplasm.