BTN3A1 and colorectal carcinoma: Moreover, Maria Raffaella Zocchi et al. (44) found that the local TME of CRC stimulated by zoledronate expresses BTN3A1/CD277 (BTN3A1 can bind to phosphoantigens and drive the activation of Vγ9Vδ2 T cells through conformational changes of the extracellular domains) to stimulate and expand effector Vγ9Vδ2 T cells that carry antitumor activity.