TNF and colorectal carcinoma: They found that disruption of CRC epithelial barrier resulted in the accumulation and activation of inflammatory DCs, and triggered γδ T17 cells polarization as well as production of IL-17, IL-8, TNF-α, and GM-CSF in γδ T cells, which promoted the recruitment and proliferation of MDSCs, and finally inhibited inflammation triggered by CRC and promoted tumorigenesis (32) (Figure 2).