PRF1 and malignant colon neoplasm: A recent study showed that Phloretin could enhance the cytolytic effects of γδ T cells on colon cancer cells by facilitating the proliferation of IFN-γ producing γδ T cells, and the underlying mechanism might be associated with the increased expression of PFP, GraB, and CD107a as well as the activation of the Wnt signaling pathway (75).