Human γδ T cells stimulated by zoledronate produced higher IFN-γ, TNF-α, granzymes, and TRAIL, thus enhancing the killing effect on the colon cancer stem cells, which was mediated by the granule exocytosis pathway and was related to the expression of isoprenoid by tumor cells (20). The gene discussed is TNFSF10; the disease is malignant colon neoplasm.