A previous study has shown that the administration of F. nucleatum in ApcMin/+ mice, which carry a point mutation in the Adenomatous Polyposis Coli (APC) gene on a single allele, accelerates the progression and carcinogenesis, provokes infiltration of specific myeloid cells into the tumor and creates a pro-inflammatory environment through the induction of the NF-κB pathway (Kostic et al., 2013). Here, APC is linked to neoplasm.