Specific COX-2 inhibitors can prevent HCMV replication and reduce the expression of US28 in tumor cells, suggesting that HCMV plays an important role in medulloblastoma and US28 is a potential therapeutic target (Maussang et al., 2009; Baryawno et al., 2011; Figure 3B). Here, PTGS2 is linked to neoplasm.