IGF1 and infection: Jiang found that the levels of thyroid hormone receptor alpha (Thra), thyroid hormone responsive protein (Thrsp) and steroid 11-beta dehydrogenase 1 (Hsd11b1) in the lungs and insulin-like growth factor 1 (Igf1) in the liver of M. fortis were significantly downregulated at 10 days post infection with S. japonicum (Jiang et al., 2010).