Thus, ICP0 can induce the destabilization of PML-NBs and centromeric chromatin, contributing to the establishment of a suitable nuclear environment for lytic infection (Lomonte and Morency, 2007; Gross et al., 2012; Wang et al., 2012), and ICP4 plays a major regulatory role in gene transcription and is necessary for HSV to undergo lytic infection (Hu et al., 2019). Here, PML is linked to infection.