ARID4B and metabolic syndrome: In addition, there was a significant reduction of the BCAA catabolic enzymes BCKDHA, BCKDHB, and BCAT2 in the visceral white adipose tissue of obese people with metabolic syndrome, leading to an increase in BCAA levels in the circulation (115), while the expression of BCAA catabolic enzymes in the adipose tissue was negatively correlated with IR (116).