ADA2 and diabetes mellitus: Decreased miR-146b-3p has been shown to be associated with increased adenosine deaminase-2 (ADA-2) activity in the vitreous of patients with diabetes, while elevated expression of miR-146b-3p suppresses the ADA2 activity and TNF-α release in amadori-glycated albumin (AGA)-treated human macrophages (205) and decreases human retinal EC permeability and leukocyte adhesion by upregulating ICAM-1 (205).