PTH and chronic kidney disease: In fact, the recommended PTH target values by CKD stage differ widely as evidenced by both the 2017 KDIGO guidelines (1), and the recent paper (2) of a pros and cons debate on this issue (28), suggesting to use trends rather than absolute target values to determine treatment decisions in children with CKD; In particular, patients with mean PTH levels >500 pg/ml showed a significant loss in height SDS compared with children with lower PTH levels (−0,28 vs. −0.05 SDS per year) (29).