In primary mouse hepatocytes, forced SIK1 expression not only promoted gluconeogenesis but also suppressed lipogenesis, as evidenced by altered SREBP-1c subcellular localization and reduced expression levels of SREBP-1c, FAS, and ACC upon additional ad-SIK1 infection, as well as diminished lipid accumulation indicated by Oil Red O staining. This evidence concerns the gene SIK1 and infection.