REN and diabetic kidney disease: The pathophysiology of DKD is primarily driven by metabolic dysregulation accompanying diabetes (hyperglycaemia, dyslipidaemia, and hypertension), and clinical management of DKD focuses on control of these inciting factors through blood pressure control, renin-angiotensin-aldosterone system (RAAS) blockade, and intensification of glycaemic and lipid control to minimise proteinuria and slow eGFR decline (7).