BDNF and myeloid sarcoma: Our study had several novel features: (1) longitutinal study that showed a sustained and durable impact of FMT on fecal microbiota community and clinical features of MS; (2) state of the art shotgun metagenomics to interrogate microbiome indicating FMT positively impacted both microbiota composition and function with increased levels of SCFA; (3) we found significant and sustained increase in serum BDNF levels, after FMTs.