NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy: <b>Introduction:</b> Cerebral autosomal dominant arteriopathy and subcortical infarct leukoencephalopathy (CADASIL) is the most common form of hereditary stroke caused by a mutation in the <i>NOTCH3</i> gene located on the short arm of chromosome 19.