Along with these anecdotal reports, a previous study reported reduced cerebral white matter (WM) global volume in patients with PMP22 deletion/duplication (8), while WM microstructural abnormalities have been recently demonstrated in a genetically heterogeneous group of CMT patients, even though no significant regional WM damage was found in CMT1A disease (9). The gene discussed is PMP22; the disease is Charcot-Marie-Tooth disease.