In fact, our group’s work demonstrates that wild type CFTR maturation from the ER through the Golgi and its function at the cell surface can be reduced by depleting ERp29 expression in IB3-1 cells and T84 colonic adenocarcinoma cells; these data were the first to describe a positive role for an ER chaperone in CFTR biogenesis. Here, CFTR is linked to colon adenocarcinoma.