IL6 and neoplasm: Blocking IL-6 signaling during exercise abolished the exercise-induced inhibition of tumor growth, suggesting that IL-6 plays a role in mediating anti-cancer effects (Aoi et al., 2013; Hojman et al., 2011; Hojman et al., 2018; Lucia and Ramirez, 2016; Manole et al., 2018; Figure 2).