Denhez et al. (2019) recently confirmed that the deletion of a family of phosphatases responsible for MAPK inhibition (dual specificity phosphatases 4) promotes podocyte dysfunction and the progression of DKD. Therefore, other key molecules that can regulate diabetic renal tubular injury through the MAPK pathway need to be studied. Next, GADD45 family members are also involved in mediating other stress-related pathways, such as the p53 pathway (Hildesheim et al., 2002). It is unclear whether the action of GADD45B on renal tubular EMT and apoptosis in DKD occurs via these signaling pathways. This evidence concerns the gene TP53 and diabetic kidney disease.