TRPV channels have been linked to atrial inotropy related to ROS-mediated signaling (Odnoshivkina et al., 2015), and in a porcine model, depletion of TRPV1 afferent fibers resulted in a reduction in ventricular arrhythmic events associated with MI (Yoshie et al., 2020). The gene discussed is TRPV1; the disease is myocardial infarction.