Its activation by GSK1702934A has been shown to influence cardiac contractility and favor rhythmic instability (Doleschal et al., 2015), and in a TRPC3 overexpression mouse model, GSK1702934A resulted in arrhythmic events including paired ventricular beats, and episodes of atrial tachycardia, ventricular tachycardia and cardiac alternans (Doleschal et al., 2015). Here, TRPC3 is linked to ventricular tachycardia.