Abnormal RyR2-mediated Ca2+ release from the SR can lead to both atrial and ventricular arrhythmias, some primary arrhythmia disorders including CPVT and forms of acquired arrhythmias associated with heart disease (AF during HF) (McCauley and Wehrens, 2011). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.