Further studies using induced pluripotent stem cells generated from a CPVT patient carrying a RyR2 mutation, showed KN-93 to drastically reduce DADs induced by catecholaminergic stress as well as stabilize Ca2+ activation under β-adrenergic stimulation to a pattern seen in normal tissue (Di Pasquale et al., 2013). The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.