The clinical importance of TRPM4 in cardiac conduction has been highlighted by studies that have identified TRPM4 mutations in numerous arrhythmic conditions including progressive cardiac bundle branch disease (Kruse et al., 2009), Brugada syndrome (Liu et al., 2013), LQT syndrome (Hof et al., 2017), atrioventricular and right bundle branch block (Stallmeyer et al., 2012), chronic heart block (Bianchi et al., 2018), and ventricular fibrillation (Bianchi et al., 2018). Here, TRPM4 is linked to Brugada syndrome.