In pre-clinical models of HF, increased SERCA2 expression through adenoviral delivery (Ad.SERCA2a) improved intracellular Ca2+ handling, restored contractility and attenuated ventricular arrhythmias (Figure 4) (del Monte et al., 2004; Lyon et al., 2011; Cutler et al., 2012). The gene discussed is ATP2A2; the disease is hydrops fetalis.