TRPC3 expression is upregulated in the atria of AF patients, and in numerous animal models of AF (Harada et al., 2012; Zhao et al., 2013), conversely, when TRPC3 expression is deleted, in a TRPC3 knockout mouse model, pacing-induced AF was significantly reduced (Ju et al., 2015). This evidence concerns the gene TRPC3 and atrial fibrillation.