Abnormal RyR2-mediated Ca2+ release from the SR can lead to both atrial and ventricular arrhythmias, some primary arrhythmia disorders including CPVT and forms of acquired arrhythmias associated with heart disease (AF during HF) (McCauley and Wehrens, 2011). The gene discussed is RYR2; the disease is Ventricular arrhythmia.