CaMKII-δ may influence cardiac hypertrophy through two distinct mechanisms which are mediated by different splice variants; CaMKII-δC regulates phosphorylation of RyR and PLN resulting in increased Ca2+ spark frequency and decreased SR Ca2+ content whereas both CaMKII-δC and CaMKII-δB variants mediate pro-hypertrophic gene transcription (Zhang et al., 2007). The gene discussed is CAMK2G; the disease is cardiac hypertrophy.