In contrast to GWAS data for ATP2B4, SNPs located in ATP2B1, the gene encoding PMCA1, have been strongly associated with CVDs, including hypertension, coronary artery disease and MI (Tabara et al., 2010; Takeuchi et al., 2010; Wang Y. et al., 2013; Xu et al., 2016; Jamshidi et al., 2018; Sombie et al., 2019). This evidence concerns the gene ATP2B1 and hypertensive disorder.