Studies have shown that enalapril ameliorated oxidative vascular injury, suppressed NADPH oxidase activity, decreased inflammatory mediators and regulated the antioxidant defense system in apolipoprotein E-deficient mice (ApoE-KO; Suarez-Martinez et al., 2014; Husain et al., 2015), an animal model commonly used to study atherosclerosis. The gene discussed is APOE; the disease is atherosclerosis.