We further examine those perturbed cancer pathways that were specifically proposed in the study that generated the data examined here, as well as others that are clinically actionable (Brastianos et al., 2015; Priedigkeit et al., 2017; Vareslija et al., 2018), i.e., ErbB, PI3K-Akt, and RET (Figure 4E). The gene discussed is AKT1; the disease is cancer.