We further examine those perturbed cancer pathways that were specifically proposed in the study that generated the data examined here, as well as others that are clinically actionable (Brastianos et al., 2015; Priedigkeit et al., 2017; Vareslija et al., 2018), i.e., ErbB, PI3K-Akt, and RET (Figure 4E). This evidence concerns the gene RET and cancer.