INS and focal segmental glomerulosclerosis: For examples, renal lipid accumulation has been shown with high clinical prevalence in patients with CKD, including the insulin resistant obese subjects with diabetic nephropathy (Herman-Edelstein et al., 2014; Escasany et al., 2019; Opazo-Ríos et al., 2020), in nephrotic syndrome (Vaziri, 2016; Agrawal et al., 2017), focal segmental glomerulosclerosis (FSGS; Sasaki et al., 2018), and also as a consequence of acute ischemic renal injury (Zager et al., 2011).