PPARGC1A and chronic kidney disease: BBR has wide spectrum pharmacological effects through its various action of mechanisms such as increasing LDL-receptor mediated hepatic clearance of LDL cholesterol (Wang et al., 2014), protection of lipid-induced apoptosis by promoting FAO in PTEC (Sun et al., 2018), supporting PGC1α-regulated mitochondrial energy homeostasis in CKD model of db/db mice and cultured podocytes (Qin et al., 2019a), and podocyte protection via inhibition of mitochondrial fission and dysfunction (Qin et al., 2019b).