ACSL1 and obesity due to melanocortin 4 receptor deficiency: In obesity-related nephropathy models, reduced NRF2 along with suppressed expression of the key FAO enzyme long-chain acyl-CoA synthetase-1 (ACSL1) are associated with elevated renal lipid deposition, further supporting the importance of mitochondria in lipid metabolism and energy homeostasis (Chen et al., 2019).