Interestingly, Jang et al. demonstrated that proximal tubular mitochondrial interaction of PPARα with cyclophilin D (CypD), a component of the IMM structural protein complex mitochondrial permeability transition pore (mPTP), could repress nuclear PPARα activity and negatively modulate FAO in cisplatin-induced AKI (Jang et al., 2020a). Here, PPARA is linked to acute kidney injury.