Similarly, Pnpla3 is a TG hydrolase with LPA transacylase activity (Jenkins et al., 2004; Lake et al., 2005; He et al., 2010); however, the physiological relevance of Pnpla3 in TG metabolism remains ambiguous as targeted deletion of Pnpla3 does not impair TG hydrolysis or promote steatosis (Basantani et al., 2011). The gene discussed is PNPLA3; the disease is steatosis.