SREBF1 and steatosis: Zhang et al. (2018) showed that treatment with fenofibrate, a synthetic PPARα ligand, and overexpression of ChREBP alleviate alcohol-related steatosis by activating FAO. Here, we found alcohol and clock-related decreases in the mesor of Mlxpil/ChREBP in the liver. Taken together, we propose that the combined effects of alcohol and clock disruption on Srebf1/SREBP-1c, Nr1h2/LXRβ, and/or Ppara rhythms impair oscillations of target FA and TG metabolism genes, contributing to steatosis.