In addition, de novo variants in KCNQ3 have been rarely described in children with DEE (Allen et al., 2013; Grozeva et al., 2015; Miceli et al., 2015; Ambrosino et al., 2018; Lauritano et al., 2019), intellectual disability (ID) apparently without epilepsy (Rauch et al., 2012; Deciphering Developmental Disorders, 2017), cortical visual impairment (Bosch et al., 2016), and in patients with ID and autism (Sands et al., 2019). The gene discussed is KCNQ3; the disease is developmental and epileptic encephalopathy.