AQP4 played an important role in regulating water balance in brain tissue, contributed to the reabsorption of cerebrospinal fluid and osmotic equilibrium, and closely related to the occurrence of cerebral edema (Papadopoulos et al., 2002; Gandham et al., 2017; Jullienne et al., 2018; Hindeya Gebreyesus and Gebrehiwot Gebremichael, 2020). The gene discussed is AQP4; the disease is brain edema.