In vitro exposure of cardiac fibroblasts to conditioned medium derived from myocardial infarction (MI)-hypoxic cardiomyocytes, led to an increase in the levels of miR-195, as well as in myofibroblast and fibrotic markers such as periostatin, alpha smooth muscle actin (α-SMA), and ColI and III on cardiac fibroblasts. Here, ACTA1 is linked to myocardial infarction.