The results of madecassoside intervention in a mouse model of osteoporosis, caused by estrogen deficiency and bone marrow monocytes showed that it can inhibit the expression of related genes by affecting the NF-κB and MAPK signaling pathways (NFATc1, c-Fos, Acp5, CTSK, VATPase-d2), inhibits the generation of osteoclasts, weaken the absorption activity of osteoclasts. This evidence concerns the gene FOS and osteoporosis.