HMOX1 and chronic obstructive pulmonary disease: In a mouse model, lung inflammation was induced by exposure to cigarette smoke, oral administration of asiatic acid reduced the excessive production of mucus in lung tissues, inhibited the release of pro-inflammatory factors, and induce the expression of HO-1, which may become a potential drug for the treatment of COPD by regulating key progressions (Lee et al., 2016; Dong et al., 2017).