At the same time, the body also has antioxidant systems including: SOD, glutathione (GSH), CAT, etc. At present, studies have shown that the mental fatigue of CFS is related to the large amount of oxygen free radicals generated in the brain and the antioxidant system is inhibited (Logan and Wong, 2001). This evidence concerns the gene SOD1 and myalgic encephalomeyelitis/chronic fatigue syndrome.