MTOR and pancreatic neoplasm: In light of our previous study suggesting that PBI-05204 down-regulated PI3K/Akt/mTOR pathway in pancreatic cancer and that this particular network is activated in almost 90% of GBM patients (Langhans et al., 2017), we first examined the expression of PI3K/Akt/mTOR signaling proteins in PBI-05204–treated U87MG cells.