PKM and neoplasm: For instance, PKM2 binds to and transactivates Y333-phosphorylated β-catenin to promote tumor cell proliferation (Yang et al., 2011); PKM2 promotes tumorigenesis by directly phosphorylating histone H3 at threonine 11 under EGFR activation (Yang et al., 2012); A recent study has demonstrated that nuclear PKM2 activates transcription of MEK5 by phosphorylating STAT3 at tyrosine 705 in colon cancer cells (Gao et al., 2012).