PKM and breast cancer: Previous reports suggested that PKM2 affects cell proliferation, migration, invasion, apoptosis, and cell cycle progression of tumors, including breast cancer, prostate cancer, myeloma, liver cancer, lung cancer, and pancreatic cancer (Stetak et al., 2007; Christofk et al., 2008; Yang et al., 2012; Jiang et al., 2014; Christensen et al., 2015; Azoitei et al., 2016; Matsuda et al., 2016; Shen et al., 2016; Guo et al., 2017).