It has been previously shown that glycolytic enzyme PKM2 which PKM2/NF-κB/miR-148a/152 feedback circuit can regulate breast cancer cells growth and angiogenesis (Yan et al., 2017), but the regulatory mechanism of PKM2 as a protein kinase on breast cancer cell proliferation and migration remains to be further explored. The gene discussed is HK1; the disease is breast carcinoma.