For instance, PKM2 binds to and transactivates Y333-phosphorylated β-catenin to promote tumor cell proliferation (Yang et al., 2011); PKM2 promotes tumorigenesis by directly phosphorylating histone H3 at threonine 11 under EGFR activation (Yang et al., 2012); A recent study has demonstrated that nuclear PKM2 activates transcription of MEK5 by phosphorylating STAT3 at tyrosine 705 in colon cancer cells (Gao et al., 2012). Here, PKM is linked to malignant colon neoplasm.