HMGB1 and digestive system neoplasm: During liver IR, ROS promote expression of the early response transcription factor IRF-1, enhance activity of histone acetyl transferase, and promotes acetylation of HMGB1 (Tsung et al., 2007; Doyle and Fitzpatrick, 2010; Evankovich et al., 2010; Yu et al., 2017).