With the development of AKI, a large amount of ROS are produced, which leads to the activation of The NLR family pyrin domain-containing 3 (NLRP3) inflammasome and the cleavage of caspase-1, thereby promoting the maturation of inflammatory cytokines and promoting the release of interleukin (IL)-1β and IL-18 (Kim et al., 2019; Zahid et al., 2019). The gene discussed is IL1B; the disease is acute kidney injury.