NFKB1 and asthma: In response to allergen challenge, cytokines, chemokines, and bacterial and viral infections, NF-κB acting as a proinflammatory transcription factor binds to the proinflammatory genes promoter region, and thereby upregulates the expression of many mediators and growth factors important in inflammatory cascade of asthma (Adcock et al., 2008; Papi et al., 2013).